Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.

Gakis, Georgios; Morgan, Todd M; Efstathiou, Jason A; Keegan, Kirk A; Mischinger, Johannes; Todenhoefer, Tilman; Schubert, Tina; Zaid, Harras B; Hrbacek, Jan; Ali-El-Dein, Bedeir; Clayman, Rebecca H; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George; Stenzl, Arnulf; ... (2016). Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma. World journal of urology, 34(1), pp. 97-103. Springer 10.1007/s00345-015-1583-7

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PURPOSE

To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).

METHODS

A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.

RESULTS

Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).

CONCLUSIONS

These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Thalmann, George

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0724-4983

Publisher:

Springer

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

24 Jun 2015 08:24

Last Modified:

04 Aug 2022 11:24

Publisher DOI:

10.1007/s00345-015-1583-7

PubMed ID:

25981402

BORIS DOI:

10.7892/boris.69763

URI:

https://boris.unibe.ch/id/eprint/69763

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