Induction of Fear by Intraoperative Stimulation During Awake Craniotomy: Case Presentation and Systematic Review of the Literature.

Nowacki, Andreas; Seidel, Kathleen; Schucht, Philippe; Schindler, Kaspar Anton; Abela, Eugenio; Heinemann, Dorothea; Gutbrod, Klemens; Wiest, Roland; Raabe, Andreas; Pollo, Claudio (2015). Induction of Fear by Intraoperative Stimulation During Awake Craniotomy: Case Presentation and Systematic Review of the Literature. World neurosurgery, 84(2), pp. 470-474. Elsevier 10.1016/j.wneu.2015.03.056

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PURPOSE A case is presented and a systematic review of the literature is provided to update our current knowledge of induction of fear by cortical stimulation. METHODS We present a case of refractory epilepsy associated with a lesion where fear could be induced by intraoperative electrical stimulation of the posterior inner part of the superior temporal gyrus. We performed a systematic review of the literature using PubMed with the key words "epilepsy AND emotion", "cortical stimulation AND emotion," and "human brain stimulation AND behavior". RESULTS Intraoperative cortical stimulation of the inner part of the posterior superior temporal gyrus reliably induced fear and progressive screaming behavior. Stimulation through subdural grid electrodes did not induce this phenomenon. A systematic review of the literature identified fear induction by stimulation of different widespread cortical areas including the temporal pole, the insula, and the anterior cingulate cortex. The posterior part of the superior temporal gyrus has so far not been associated with fear induction after electrical stimulation. CONCLUSION Although our observation suggests that this area of the brain could be part of a network involved in the elicitation of fear, dysfunction of this network induced by epilepsy could also explain the observed phenomenon. Electrophysiologic and imaging studies must be conducted to improve our understanding of the cortical networks forming the neuroanatomical substrate of higher brain functions and experiences such as fear.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Nowacki, Andreas; Seidel, Kathleen; Schucht, Philippe; Schindler, Kaspar Anton; Abela, Eugenio; Gutbrod, Klemens; Wiest, Roland; Raabe, Andreas and Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1878-8750

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

26 Jun 2015 13:36

Last Modified:

30 Jan 2017 10:47

Publisher DOI:

10.1016/j.wneu.2015.03.056

PubMed ID:

25862115

Uncontrolled Keywords:

Awake craniotomy; Direct cortical stimulation; Induction of fear; Temporal lobe epilepsy

BORIS DOI:

10.7892/boris.69816

URI:

https://boris.unibe.ch/id/eprint/69816

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