Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.

Hewer, Ekkehard; Beck, Jürgen; Kellner-Weldon, Frauke; Vajtai, Istvan (2015). Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain. Human pathology, 46(7), pp. 1045-1049. Elsevier 10.1016/j.humpath.2015.03.005

[img] Text
1-s2.0-S0046817715000891-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy

Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Variously interpreted as either astrocytic- or ependymal-like, and speculatively ascribed to the lamina terminalis/subcommissural organ, its histogenesis remains, nevertheless, unsettled. Here, we report on a suprasellar chordoid glioma occurring in a 52-year-old man. Although displaying otherwise typical morphological features, the tumor was notable for expression of thyroid transcription factor 1, a marker of tumors of pituicytic origin in the context of the sellar region. We furthermore found overlapping immunoprofiles of this example of chordoid glioma and pituicytic tumors (pituicytoma and spindle cell oncocytoma), respectively. Specifically, phosphorylated ribosomal protein S6, a marker of mTOR pathway activation, was expressed in both groups. Based on these findings, we suggest that chordoid glioma and pituicytic tumors may form part of a spectrum of lineage-related neoplasms of the basal forebrain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Hewer, Ekkehard; Beck, Jürgen; Kellner-Weldon, Frauke and Vajtai, Istvan

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0046-8177

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

26 Jun 2015 13:20

Last Modified:

29 Oct 2015 11:41

Publisher DOI:

10.1016/j.humpath.2015.03.005

PubMed ID:

25934249

Uncontrolled Keywords:

Chordoid glioma of the third ventricle; Histogenesis; Mammalian target of rapamycin; Pituicytoma; Spindle cell oncocytoma of the adenohypophysis; Thyroid transcription factor 1

BORIS DOI:

10.7892/boris.69818

URI:

https://boris.unibe.ch/id/eprint/69818

Actions (login required)

Edit item Edit item
Provide Feedback