High-flow venous pouch aneurysm in the rabbit carotid artery: A model for large aneurysms.

Krähenbühl, Anna Katharina; Gralla, Jan; Abu-Isa, Janine; Mordasini, Pasquale; Widmer, Hans Rudolf; Raabe, Andreas; Reinert, Michael (2015). High-flow venous pouch aneurysm in the rabbit carotid artery: A model for large aneurysms. Interventional neuroradiology, 21(3), pp. 407-411. Sage Publications 10.1177/1591019915582381

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BACKGROUND AND PURPOSE Currently one of the most widely used models for the development of endovascular techniques and coiling devices for treatment of aneurysm is the elastase-induced aneurysm model in the rabbit carotid artery. Microsurgical techniques for creating an aneurysm with a venous pouch have also been established, although both techniques usually result in aneurysms less than 1 cm in diameter. We investigated whether an increase in blood flow toward the neck would produce larger aneurysms in a microsurgical venous pouch model. MATERIALS AND METHODS Microsurgical operations were performed on 11 New Zealand white rabbits. Both carotid arteries and the right jugular vein were dissected, and the right carotid artery was temporarily clipped followed by an arteriotomy. The left carotid artery was also clipped proximally, ligated distally, and sutured onto the proximal half of the arteriotomy in the right carotid artery. The venous graft was sutured onto the distal half of the arteriotomy. Digital subtraction angiography was also performed. RESULTS Angiography showed patent anastomosed vessels and aneurysms in the seven surviving rabbits. Mean aneurysm measurements among surviving rabbits with patent vessels were: 13.9 mm length, 9.3 mm width, and neck diameter 4.7 mm. The resulting mean aspect ratio was 3.35 and the mean bottleneck ratio was 3.05. CONCLUSION A large venous graft and increased blood flow toward the base of the aneurysm seem to be key factors in the creation of large venous pouch aneurysms. These large aneurysms allow testing of endovascular devices designed for large and giant aneurysms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Krähenbühl, Anna Katharina; Gralla, Jan; Abu-Isa, Janine; Mordasini, Pasquale; Widmer, Hans Rudolf; Raabe, Andreas and Reinert, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1591-0199

Publisher:

Sage Publications

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

26 Jun 2015 13:58

Last Modified:

14 Sep 2017 09:14

Publisher DOI:

10.1177/1591019915582381

PubMed ID:

26015528

Uncontrolled Keywords:

Aneurysm; animal models; carotid aneurysm; cerebrovascular circulation

BORIS DOI:

10.7892/boris.69819

URI:

https://boris.unibe.ch/id/eprint/69819

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