Inflammation and nerve fiber interaction in endometriotic pain.

Mc Kinnon, Brett; Bertschi, Dominic; Bersinger, Nick A.; Mueller, Michael (2015). Inflammation and nerve fiber interaction in endometriotic pain. Trends in endocrinology and metabolism, 26(1), pp. 1-10. Elsevier Current Trends 10.1016/j.tem.2014.10.003

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Endometriosis is an extremely prevalent estrogen-dependent condition characterized by the growth of ectopic endometrial tissue outside the uterine cavity, and is often presented with severe pain. Although the relationship between lesion and pain remains unclear, nerve fibers found in close proximity to endometriotic lesions may be related to pain. Also, women with endometriosis pain develop central sensitization. Endometriosis creates an inflammatory environment and recent research is beginning to elucidate the role of inflammation in stimulating peripheral nerve sensitization. In this review, we discuss endometriosis-associated inflammation, peripheral nerve fibers, and assess their potential mechanism of interaction. We propose that an interaction between lesions and nerve fibers, mediated by inflammation, may be important in endometriosis-associated pain.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Mc Kinnon, Brett; Bersinger, Nick A. and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-2760

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Monika Zehr

Date Deposited:

29 Jun 2015 17:03

Last Modified:

07 Nov 2016 09:55

Publisher DOI:

10.1016/j.tem.2014.10.003

PubMed ID:

25465987

Uncontrolled Keywords:

endometriosis; inflammation; nerve; pain

BORIS DOI:

10.7892/boris.69834

URI:

https://boris.unibe.ch/id/eprint/69834

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