Is Parkinson's disease of early onset a separate disease entity?

Ludin, Sabina; Ludin, Hans-Peter (1989). Is Parkinson's disease of early onset a separate disease entity? Journal of neurology, 236(4), pp. 203-207. Springer-Medizin-Verlag 10.1007/BF00314500

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Two groups of patients suffering from Parkinson's disease were studied. The first group consisted of 23 patients with an onset age before 40 years; in the second group of 21 patients the onset was after age 50. The clinical findings and the course of the disease were very similar in each group. In spite of a longer disease duration in the patients with early onset of the disease there was no difference in motor impairment; the younger patients did better in mental testing and they were taking less dopaminergic medication. These differences are thought to be due to the age difference rather than to the existence of different disease entities. In the early onset group more familial cases (mostly affecting siblings) were found than in the older ones. The points in favour of there being a hereditary subgroup of early onset Parkinson's disease or of environmental factors causing the disease are reviewed.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Ludin, Sabina and Ludin, Hans-Peter


600 Technology > 610 Medicine & health








Sabina Ludin

Date Deposited:

29 Jun 2015 11:29

Last Modified:

29 Jun 2015 11:29

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