Autonomic disturbances and cardiovascular reflexes in idiopathic Parkinson's disease

Ludin, Sabina; Steiger, Ursula; Ludin, Hans-Peter (1987). Autonomic disturbances and cardiovascular reflexes in idiopathic Parkinson's disease. Journal of neurology, 235(1), pp. 10-15. Springer-Medizin-Verlag 10.1007/BF00314190

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A total of 22 patients suffering from idiopathic Parkinson's disease and 20 age-matched volunteers were questioned about autonomic disturbances and all underwent four non-invasive tests examining cardiovascular reflexes. Significantly more autonomic disturbances were reported by the patients than by the controls. Resting blood pressure was significantly decreased in patients taking dopamine agonists, whereas it was normal in those patients who only received levodopa and anticholinergics. Resting heart rate and resting beat-to-beat variation were normal in the patients, as were the blood pressure response to standing and the postural heart rate response. No pathological response to the Valsalva manoeuvre could be detected. On the other hand, the heart rate variation evoked by deep breathing as well as the blood pressure response and the heart rate response to sustained isometric exercise were significantly diminished in the patients with idiopathic Parkinson's disease. These findings indicate a central disturbance of cardiovascular reflex control, whereas the corresponding peripheral pathways seem to be normal.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary Medicine (ICOM)

UniBE Contributor:

Ludin, Sabina and Ludin, Hans-Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-5354

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Sabina Ludin

Date Deposited:

29 Jun 2015 11:33

Last Modified:

29 Jun 2015 11:33

Publisher DOI:

10.1007/BF00314190

PubMed ID:

3430178

URI:

https://boris.unibe.ch/id/eprint/69852

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