Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies.

Liechti, Fabian D; Grandgirard, Denis; Leib, Stephen (2015). Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies. Future microbiology, 10(7), pp. 1195-1213. Future Medicine 10.2217/fmb.15.43

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ABSTRACT  Bacterial meningitis is associated with high mortality and morbidity rates. Bacterial components induce an overshooting inflammatory reaction, eventually leading to brain damage. Pathological correlates of neurofunctional deficits include cortical necrosis, damage of the inner ear and hippocampal apoptosis. The hippocampal dentate gyrus is important for memory acquisition and harbors a neuronal stem cell niche, thus being potentially well equipped for regeneration. Adjuvant therapies aimed at decreasing the inflammatory reaction, for example, dexamethasone, and those protecting the brain from injury have been evaluated in animal models of the disease. They include nonbacteriolytic antibiotics (e.g., daptomycin), metalloproteinase inhibitors and modulators of the immunological response, for example, granulocyte colony-stimulating factor. Increasing research interest has recently been focused on interventions aimed at supporting regenerative processes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Grandgirard, Denis and Leib, Stephen

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1746-0921

Publisher:

Future Medicine

Funders:

[4] Swiss National Science Foundation
[24] Gottfried und Julia Bangerter- Rhyner Stiftung

Language:

English

Submitter:

Stephen Leib

Date Deposited:

03 Jul 2015 14:15

Last Modified:

08 Feb 2017 14:36

Publisher DOI:

10.2217/fmb.15.43

PubMed ID:

26119836

Uncontrolled Keywords:

Streptococcus pneumoniae; animal model; bacterial meningitis; brain injury; dentate gyrus; neurogenesis; neuroinfection; neuroinflammation

BORIS DOI:

10.7892/boris.69897

URI:

https://boris.unibe.ch/id/eprint/69897

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