Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease

Wustmann, Kerstin; Klaey, Marco; Burow, Annika; Shaw, Sidney G; Hess, Otto M; Allemann, Yves (2012). Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease. Cardiovascular therapeutics, 30(5), pp. 277-86. Oxford: Blackwell 10.1111/j.1755-5922.2011.00272.x

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Endothelial dysfunction is a marker for development and progression of atherosclerosis. Statin therapy improves endothelial function in cardiovascular patients by reducing LDL-cholesterol and by pleiotropic effects. B-group vitamin supplementation restores endothelial function mainly by reducing homocysteine-induced oxidative stress. Thus, we evaluated the effect of rosuvastatin, B-group vitamins and their combination on endothelial function in high-risk cardiovascular patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Tiefenau Hospital [discontinued] > Forschungsgruppe Vasoaktive Peptide [discontinued]

UniBE Contributor:

Wustmann, Kerstin Brigitte; Shaw, Sidney; Hess, Otto and Allemann, Yves

ISSN:

1755-5914

Publisher:

Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

Publisher DOI:

10.1111/j.1755-5922.2011.00272.x

PubMed ID:

21884007

Web of Science ID:

000308482800010

URI:

https://boris.unibe.ch/id/eprint/7006 (FactScience: 212142)

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