Neurotensin receptors in pancreatic ductal carcinomas.

Körner Jachertz, Meike; Waser, Beatrice; Strobel, Oliver; Büchler, Markus; Reubi, Jean Claude (2015). Neurotensin receptors in pancreatic ductal carcinomas. EJNMMI research, 5(17), p. 17. Springer 10.1186/s13550-015-0094-2

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BACKGROUND

The frequent expression of neurotensin receptors (NT-R) in primaries of pancreatic ductal carcinomas has triggered the development of radioactive neurotensin analogs for possible in vivo targeting of these tumors. However, the complete lack of information regarding NT-R in liver metastases of pancreatic cancer and pancreatic intraepithelial neoplasia (PanIN) makes an in vitro study of NT-R in these tissues indispensable.

METHODS

Using in vitro receptor autoradiography with (125)I-[Tyr(3)]-neurotensin, NT-R were investigated in 18 primaries and 23 liver metastases of pancreatic ductal carcinomas as well as in 19 PanIN lesions.

RESULTS

We report here that 13 of 18 ductal carcinoma primaries and 14 of 23 liver metastases expressed NT-R. Moreover, none of the six PanIN 1B cases expressed NT-R, while two of six PanIN 2 and five of seven PanIN 3 expressed NT-R. Binding was fully displaced by the type 1 NT-R-selective antagonist SR48692, indicating that the NT-R in the tumors are of the type 1 NT-R subtype.

CONCLUSIONS

These in vitro data extend the currently available information on NT-R in invasive and non-invasive pancreatic ductal tumors. They suggest that type 1 NT-R may be a novel, specific marker of PanIN of higher degree. The high expression of NT-R in primaries and metastases of invasive cancer strongly support the need to develop radioactive neurotensin analogs for the diagnosis and therapy of this tumor type.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Körner Jachertz, Meike; Waser, Beatrice and Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2191-219X

Publisher:

Springer

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

13 Jul 2015 09:51

Last Modified:

17 Oct 2019 11:10

Publisher DOI:

10.1186/s13550-015-0094-2

PubMed ID:

25859423

Uncontrolled Keywords:

Liver metastasis; Neurotensin receptors; Pancreatic ductal carcinomas; Pancreatic intraepithelial neoplasia; Tumor imaging

BORIS DOI:

10.7892/boris.70211

URI:

https://boris.unibe.ch/id/eprint/70211

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