Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Pajtler, Kristian W; Witt, Hendrik; Sill, Martin; Jones, David T W; Hovestadt, Volker; Kratochwil, Fabian; Wani, Khalida; Tatevossian, Ruth; Punchihewa, Chandanamali; Johann, Pascal; Reimand, Jüri; Warnatz, Hans-Jörg; Ryzhova, Marina; Mack, Steve; Ramaswamy, Vijay; Capper, David; Schweizer, Leonille; Sieber, Laura; Wittmann, Andrea; Huang, Zhiqin; ... (2015). Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer cell, 27(5), pp. 728-743. Cell Press 10.1016/j.ccell.2015.04.002

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Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

Hewer, Ekkehard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1535-6108

Publisher:

Cell Press

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

14 Jul 2015 11:07

Last Modified:

04 Nov 2016 16:14

Publisher DOI:

10.1016/j.ccell.2015.04.002

PubMed ID:

25965575

BORIS DOI:

10.7892/boris.70226

URI:

https://boris.unibe.ch/id/eprint/70226

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