Current developments in the use of stem cell for therapeutic neovascularisation: is the future therapy "cell-free"?

Yang, Zijiang; Di Santo, Stefano; Kalka, Christoph (2010). Current developments in the use of stem cell for therapeutic neovascularisation: is the future therapy "cell-free"? Swiss medical weekly, 140, w13130. EMH Schweizerischer Ärzteverlag 10.4414/smw.2010.13130

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The plasticity and self-regenerative properties of stem cells have opened new avenues in regenerative medicine. Greater understanding of the biology of stem cells is followed by growing expectations of a rapid translation into alternative therapeutic options. Recent preclinical studies and clinical trials employing stem and progenitor cells from different sources have shown encouraging results. However, their underlying mechanisms are still poorly understood, the potential adverse effects and the discrepancy in efficacy remain to be further investigated. Their essential role in vessel regeneration has made endothelial progenitor cells (EPC) a suitable candidate for therapeutic applications aiming at tissue revascularisation. Recent evidence suggests that EPC contribute to neovascularisation not only by direct participation in tissue homeostasis but mainly via paracrine mechanisms. In future, novel therapeutic strategies could be based on EPC paracrine factors or synthetic factors, and replace cell transplantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Angiologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Yang, Zijiang and Di Santo, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Users 22 not found.

Date Deposited:

13 Jul 2015 11:53

Last Modified:

13 Jul 2015 15:02

Publisher DOI:

10.4414/smw.2010.13130

PubMed ID:

21170763

BORIS DOI:

10.7892/boris.70239

URI:

https://boris.unibe.ch/id/eprint/70239

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