Novel targeted therapies for eosinophil-associated diseases and allergy.

Radonjic-Hoesli, Susanne; Valent, Peter; Klion, Amy D; Wechsler, Michael E; Simon, Hans-Uwe (2015). Novel targeted therapies for eosinophil-associated diseases and allergy. Annual review of pharmacology and toxicology, 55, pp. 633-656. Annual Reviews Inc. 10.1146/annurev-pharmtox-010814-124407

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Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0362-1642

Publisher:

Annual Reviews Inc.

Language:

English

Submitter:

Debora Scherrer

Date Deposited:

24 Jul 2015 08:20

Last Modified:

26 May 2016 10:23

Publisher DOI:

10.1146/annurev-pharmtox-010814-124407

PubMed ID:

25340931

Uncontrolled Keywords:

asthma; biologicals; chronic eosinophilic leukemia; hypereosinophilic syndrome; tyrosine kinase inhibitors

BORIS DOI:

10.7892/boris.70446

URI:

https://boris.unibe.ch/id/eprint/70446

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