Amicrobial pustulosis-like rash in a patient with Crohn's disease under anti-TNF-alpha blocker

Lee, Haur Yueh; Pelivani, Nedzmidin; Beltraminelli, Helmut; Hegyi, Ivan; Yawalkar, Nikhil; Borradori, Luca (2011). Amicrobial pustulosis-like rash in a patient with Crohn's disease under anti-TNF-alpha blocker. Dermatology, 222(4), pp. 304-10. Basel: Karger 10.1159/000329428

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Amicrobial pustulosis of the folds (APF) is a recently described entity characterized by relapsing pustular lesions predominantly involving the cutaneous flexures and scalp. This disease typically occurs in association with systemic lupus erythematosus and a variety of other autoimmune diseases. We here describe an APF-like pustular eruption predominantly affecting the scalp, face and trunk, occurring during long-term infliximab treatment for Crohn's disease. Immunohistochemical staining of skin biopsy specimens for myxovirus resistance protein A, a marker for type 1 interferon-inducible proteins, showed increased staining in the epidermis and dermal mononuclear inflammatory infiltrate. Our observation further extends the spectrum of cutaneous adverse reactions potentially related to anti-tumor necrosis factor-α, the clinical context in which APF can occur as well as its clinical presentations.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Pelivani, Nedzmidin; Beltraminelli, Helmut; Yawalkar, Nikhil and Borradori, Luca








Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

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URI: (FactScience: 212194)

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