Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis.

Liu, He; He, Zhaoyue; Simon, Hans-Uwe (2015). Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis. Journal of molecular medicine JMM, 93(2), pp. 159-164. Springer 10.1007/s00109-014-1241-3

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Autophagy, a fundamental cellular catabolic process, is involved in the development of numerous diseases including cancer. Autophagy seems to have an ambivalent impact on tumor development. While increasing evidence indicates a cytoprotective role for autophagy that can contribute to resistance against chemotherapy and even against the adverse, hypoxic environment of established tumors, relatively few publications focus on the role of autophagy in early tumorigenesis. However, the consensus is that autophagy is inhibitory for the genesis of tumors. To understand this apparent contradiction, more detailed information about the roles of the individual participants in autophagy is needed. This review will address this topic with respect to autophagy-related protein 5 (ATG5), which in several lines of investigation has been ascribed special significance in the autophagic pathway. Furthermore, it was recently shown that an ATG5 deficiency in melanocytes interferes with oncogene-induced senescence, thus promoting melanoma tumorigenesis. Similarly, an ATG5 deficiency resulted in tumors of the lung and liver in experimental mouse models. Taken together, these findings indicate that ATG5 and the autophagy to which it contributes are essential gatekeepers restricting early tumorigenesis in multiple tissues.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Liu, He; He, Zhaoyue and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0946-2716

Publisher:

Springer

Language:

English

Submitter:

Debora Scherrer

Date Deposited:

24 Jul 2015 08:10

Last Modified:

26 May 2016 10:22

Publisher DOI:

10.1007/s00109-014-1241-3

PubMed ID:

25529049

Uncontrolled Keywords:

Adenoma; Autophagy; ATG5; Melanoma; Oncogenesis; Senescence; Tumorigenesis

BORIS DOI:

10.7892/boris.70454

URI:

https://boris.unibe.ch/id/eprint/70454

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