The future of fluorides and other protective agents in erosion prevention

Lussi, Adrian; Saads Carvalho, Thiago (2015). The future of fluorides and other protective agents in erosion prevention. Caries research, 49(Suppl 1), pp. 18-29. Karger 10.1159/000380886

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The effectiveness of fluoride in caries prevention has been convincingly proven. In recent years, researchers have investigated the preventive effects of different fluoride formulations on erosive tooth wear with positive results, but their action on caries and erosion prevention must be based on different requirements, because there is no sheltered area in the erosive process as there is in the subsurface carious lesions. Thus, any protective mechanism from fluoride concerning erosion is limited to the surface or the near surface layer of enamel. However, reports on other protective agents show superior preventive results. The mechanism of action of tin-containing products is related to tin deposition onto the tooth surface, as well as the incorporation of tin into the near-surface layer of enamel. These tin-rich deposits are less susceptible to dissolution and may result in enhanced protection of the underlying tooth. Titanium tetrafluoride forms a protective layer on the tooth surface. It is believed that this layer is made up of hydrated hydrogen titanium phosphate. Products containing phosphates and/or proteins may adsorb either to the pellicle, rendering it more protective against demineralization, or directly to the dental hard tissue, probably competing with H(+) at specific sites on the tooth surface. Other substances may further enhance precipitation of calcium phosphates on the enamel surface, protecting it from additional acid impacts. Hence, the future of fluoride alone in erosion prevention looks grim, but the combination of fluoride with protective agents, such as polyvalent metal ions and some polymers, has much brighter prospects.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > School of Dental Medicine > Restorative Dentistry, Research
04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Lussi, Adrian, Saads Carvalho, Thiago


600 Technology > 610 Medicine & health








Thiago Saads Carvalho

Date Deposited:

29 Jul 2015 11:44

Last Modified:

05 Dec 2022 14:48

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Arginine, Casein, Chitosan, Erosive tooth wear, Fluoride, Mucin, Prevention, Salivary pellicle, Sodium hexametaphosphate, Stannous fluoride, Titanium tetrafluoride




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