Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study

Di Zenzo, Giovanni; Thoma-Uszynski, Sybille; Calabresi, Valentina; Fontao, Lionel; Hofmann, Silke C; Lacour, Jean-Philippe; Sera, Francesco; Bruckner-Tuderman, Leena; Zambruno, Giovanna; Borradori, Luca; Hertl, Michael (2011). Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study. Journal of Investigative Dermatology, 131(11), pp. 2271-80. New York, N.Y.: Nature Publishing 10.1038/jid.2011.180

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Bullous pemphigoid (BP), the most common autoimmune subepidermal bullous disease, is associated with an autoantibody response to BP180 and BP230, two components of junctional adhesion complexes in human skin promoting dermo-epidermal cohesion. Retrospective analyses demonstrated that these autoantigens harbor several epitopes targeted by autoaggressive B and T cells. The aim of this prospective multicenter study was to assess the evolution of IgG autoantibodies in 35 BP patients over a 12-month observation period. Epitope-spreading (ES) events were detected in 17 of 35 BP patients (49%). They preferentially occurred in an early stage of the disease and were significantly related to disease severity at diagnosis. Moreover, in three patients, spreading of IgG reactivity to intracellular epitopes of BP180 and BP230 was preceded by recognition of the BP180 ectodomain. Finally, IgG reactivity with extracellular epitopes of BP180 and intracellular epitopes of BP230 correlated with the severity of BP in disease course. These findings support the idea that IgG recognition of the BP180 ectodomain is an early and crucial event in BP disease, followed by variable intra- and intermolecular ES events, which likely shape the individual course of BP.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Borradori, Luca

ISSN:

0022-202X

Publisher:

Nature Publishing

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

04 Apr 2014 21:50

Publisher DOI:

10.1038/jid.2011.180

PubMed ID:

21697892

Web of Science ID:

000296240100022

URI:

https://boris.unibe.ch/id/eprint/7055 (FactScience: 212204)

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