Genetic analysis of white facial and leg markings in the Swiss Franches-Montagnes Horse Breed

Rieder, Stefan; Hagger, Christian; Obexer-Ruff, Gabriela; Leeb, Tosso; Poncet, Pierre-André (2008). Genetic analysis of white facial and leg markings in the Swiss Franches-Montagnes Horse Breed. Journal of heredity, 99(2), pp. 130-136. Oxford University Press 10.1093/jhered/esm115

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White markings and spotting patterns in animal species are thought to be a result of the domestication process. They often serve for the identification of individuals but sometimes are accompanied by complex pathological syndromes. In the Swiss Franches-Montagnes horse population, white markings increased vastly in size and occurrence during the past 30 years, although the breeding goal demands a horse with as little depigmented areas as possible. In order to improve selection and avoid more excessive depigmentation on the population level, we estimated population parameters and breeding values for white head and anterior and posterior leg markings. Heritabilities and genetic correlations for the traits were high (h(2) > 0.5). A strong positive correlation was found between the chestnut allele at the melanocortin-1-receptor gene locus and the extent of white markings. Segregation analysis revealed that our data fit best to a model including a polygenic effect and a biallelic locus with a dominant-recessive mode of inheritance. The recessive allele was found to be the white trait-increasing allele. Multilocus linkage disequilibrium analysis allowed the mapping of the putative major locus to a chromosomal region on ECA3q harboring the KIT gene.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Leeb, Tosso

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0022-1503

Publisher:

Oxford University Press

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

17 Aug 2015 14:19

Last Modified:

23 Oct 2019 09:17

Publisher DOI:

10.1093/jhered/esm115

PubMed ID:

18296388

BORIS DOI:

10.7892/boris.70785

URI:

https://boris.unibe.ch/id/eprint/70785

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