Ectodysplasin-1 deficiency in a German Holstein bull associated with loss of respiratory mucous glands and chronic rhinotracheitis

Seeliger, F; Drögemüller, Cord; Tegtmeier, P; Baumgärtner, W; Distl, O; Leeb, Tosso (2005). Ectodysplasin-1 deficiency in a German Holstein bull associated with loss of respiratory mucous glands and chronic rhinotracheitis. Journal of comparative pathology, 132(4), pp. 346-349. Elsevier 10.1016/j.jcpa.2004.11.001

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A 2-year-old German Holstein bull was identified as a carrier of a mutation within the X-chromosomal ED1 gene, which encodes a TNF-related signalling molecule mainly involved in ectodermal development. The clinicopathological appearance was associated with hypotrichosis, hypodontia, and a reduced number of eccrine glands, in addition to chronic rhinotracheitis and partial squamous metaplasia. Furthermore, for the first time in an ED1-deficient animal, a complete lack of respiratory mucous glands was observed. This suggests that the ED1 gene plays a role in the development of mucous glands, the absence of which resembles a feature of X-linked anhidrotic ectodermal dysplasia (ED1) in human patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Drögemüller, Cord and Leeb, Tosso

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

17 Aug 2015 16:11

Last Modified:

18 Aug 2015 01:15

Publisher DOI:

10.1016/j.jcpa.2004.11.001

PubMed ID:

15893993

BORIS DOI:

10.7892/boris.70802

URI:

https://boris.unibe.ch/id/eprint/70802

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