Atopic dermatitis - from new pathophysiologic insights to individualized therapy

Novak, Natalija; Simon, D (2011). Atopic dermatitis - from new pathophysiologic insights to individualized therapy. Allergy, 66(7), pp. 830-9. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02571.x

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Recently, important novel insights into the complex pathophysiology of atopic dermatitis (AD) have been gained. However, in most cases the therapy of AD is limited to base line therapy with emollients combined with symptomatic, rather general immunosuppressive treatment approaches of the flare-ups. Latest research findings together with experiences from daily clinical practice, which support the concept that a combination of general disease features together with specific trigger factors in the individual patients drive the disease, might be helpful for a subclassification of patients with AD based on the most relevant pathophysiologic modifications. Subclassification of patients with AD seems indispensable to introduce rationale-based, individualized treatment approaches of AD, which target specific modified pathways. In this review, we provide an overview about a selection of pathophysiologic pathways, which hold promise to represent targets of such therapeutic approaches in the near future.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Simon, Dagmar

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

Publisher DOI:

10.1111/j.1398-9995.2011.02571.x

PubMed ID:

21366605

Web of Science ID:

000291220000004

URI:

https://boris.unibe.ch/id/eprint/7084 (FactScience: 212235)

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