HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis.

Rohner, Eliane; Wyss, Natascha; Heg, Zina; Faralli, Zully; Mbulaiteye, Sam M; Novak, Urban; Zwahlen, Marcel; Egger, Matthias; Bohlius, Julia (2016). HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. International journal of cancer, 138(1), pp. 45-54. Wiley-Blackwell 10.1002/ijc.29687

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HIV-infection is an important risk factor for developing Kaposi sarcoma (KS), but it is unclear whether HIV-positive persons are also at increased risk of co-infection with human herpesvirus 8 (HHV-8), the infectious cause of KS. We systematically searched literature up to December 2012 and included studies reporting HHV-8 seroprevalence for HIV-positive and HIV-negative persons. We used random-effects meta-analysis to combine odds ratios (ORs) of the association between HIV and HHV-8 seropositivity and conducted random-effects meta-regression to identify sources of heterogeneity. We included 93 studies with 58,357 participants from 32 countries in sub-Saharan Africa, North and South America, Europe, Asia, and Australia. Overall, HIV-positive persons were more likely to be HHV-8 seropositive than HIV-negative persons (OR 1.99, 95% confidence interval [CI] 1.70-2.34) with considerable heterogeneity among studies (I(2) 84%). The association was strongest in men who have sex with men (MSM, OR 3.95, 95% CI 2.92-5.35), patients with hemophilia (OR 3.11, 95% CI 1.19-8.11), and children (OR 2.45, 95% CI 1.58-3.81), but weaker in heterosexuals who engage in low-risk (OR 1.42, 95% CI 1.16-1.74) or high-risk sexual behavior (OR 1.66, 95% CI 1.27-2.17), persons who inject drugs (OR 1.66, 95% CI 1.28-2.14), and pregnant women (OR 1.68, 95% CI 1.15-2.47), p value for interaction <0.001. In conclusion, HIV-infection was associated with an increased HHV-8 seroprevalence in all population groups examined. A better understanding of HHV-8 transmission in different age and behavioral groups is needed to develop strategies to prevent HHV-8 transmission.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Rohner, Eliane; Wyss, Natascha Marion; Heg-Bachar, Zina; Novak, Urban; Zwahlen, Marcel; Egger, Matthias and Bohlius, Julia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0020-7136

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

11 Aug 2015 16:10

Last Modified:

15 Sep 2017 09:24

Publisher DOI:

10.1002/ijc.29687

PubMed ID:

26175054

Uncontrolled Keywords:

HIV; co-infection; human herpesvirus 8; meta-analysis

BORIS DOI:

10.7892/boris.70950

URI:

https://boris.unibe.ch/id/eprint/70950

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