Cell therapies for heart function recovery: focus on myocardial tissue engineering and nanotechnologies

Giraud, Marie-Noelle; Guex, Anne Géraldine; Tevaearai, Hendrik T. (2012). Cell therapies for heart function recovery: focus on myocardial tissue engineering and nanotechnologies. Cardiology research and practice, 2012, p. 971614. Cairo (Egypt): SAGE Hindawi 10.1155/2012/971614

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Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the injection and their low survival in the hostile environment. It has indeed been demonstrated that cell mortality due to the injection approaches 90%. Major issues still need to be resolved and bed-to-bench followup is paramount to foster clinical implementations. The tissue engineering approach thus constitutes an attractive alternative since it provides the opportunity to deliver a large number of cells that are already organized in an extracellular matrix. Recent laboratory reports confirmed the interest of this approach and already encouraged a few groups to investigate it in clinical studies. We discuss current knowledge regarding engineered tissue for myocardial repair or replacement and in particular the recent implementation of nanotechnological approaches.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Giraud, Marie-Noelle and Tevaearai, Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2090-8016

Publisher:

SAGE Hindawi

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

08 Jan 2015 03:26

Publisher DOI:

10.1155/2012/971614

PubMed ID:

22577591

BORIS DOI:

10.7892/boris.7114

URI:

https://boris.unibe.ch/id/eprint/7114 (FactScience: 212288)

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