Electric pulses augment reporter gene expression in the beating heart

Eigeldinger-Berthou, Sylvie; Buntschu, Patrick; Flück, Martin; Frobert, Aurélien; Ferrié, Céline; Carrel, Thierry P; Tevaearai, Hendrik T; Kadner, Alexander (2012). Electric pulses augment reporter gene expression in the beating heart. Journal of gene medicine, 14(3), pp. 191-203. Chichester: Wiley 10.1002/jgm.2603

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Gene therapy of the heart has been attempted in a number of clinical trials with the injection of naked DNA, although quantitative information on myocellular transfection rates is not available. The present study aimed to quantify the efficacy of electropulsing protocols that differ in pulse duration and number to stimulate transfection of cardiomyocytes and to determine the impact on myocardial integrity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Buntschu, Patrick; Carrel, Thierry; Tevaearai, Hendrik and Kadner, Alexander

ISSN:

1099-498X

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

Publisher DOI:

10.1002/jgm.2603

PubMed ID:

22262642

Web of Science ID:

000301710400007

URI:

https://boris.unibe.ch/id/eprint/7120 (FactScience: 212294)

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