Genotypes and antibiotic resistance of bovine Campylobacter and their contribution to human campylobacteriosis

Jonas, Romie; Kittl, Sonja; Overesch, Gudrun; Kuhnert, Peter (2015). Genotypes and antibiotic resistance of bovine Campylobacter and their contribution to human campylobacteriosis. Epidemiology and infection, 143(11), pp. 2373-2380. Cambridge University Press 10.1017/S0950268814003410

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Campylobacter jejuni and Campylobacter coli are the most important bacterial causes of human gastroenteritis. Chicken has been recognized as a major source for human infection, whereas cattle might also contribute to a lesser extent. However, there is a paucity of information available regarding Campylobacter in Swiss cattle and their role for human campylobacteriosis. To gain more information on genotypes and antibiotic resistance of bovine C. jejuni and C. coli and on their contribution to human disease, 97 cattle isolates were analysed. Multilocus sequence typing (MLST) and flaB typing were applied and the gyrA and 23S rRNA genes were screened for point mutations responsible for quinolone and macrolide resistance, respectively. A total of 37 sequence types (STs) and 44 flaB types were identified, including two sequence types and five flaB types not previously described. Most common sequence types were ST21 (21%), ST61 (12%) and ST48 (11%). Only one isolate was macrolide resistant while 31% (n = 30) were quinolone resistant. Source attribution indicated chicken as the main source of human infection with cattle being second. In conclusion, cattle should not be underestimated as a potential source of human campylobacteriosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Jonas, Romie; Kittl, Sonja; Overesch, Gudrun and Kuhnert, Peter

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

0950-2688

Publisher:

Cambridge University Press

Language:

English

Submitter:

Peter Kuhnert-Ryser

Date Deposited:

17 Sep 2015 09:15

Last Modified:

23 Oct 2019 06:42

Publisher DOI:

10.1017/S0950268814003410

PubMed ID:

25511436

Uncontrolled Keywords:

Antibiotic resistance; Campylobacter coli ; Campylobacter jejuni ; flaB ; gastroenteritis; genoptyping; MLST; source attribution; zoonosis

BORIS DOI:

10.7892/boris.71679

URI:

https://boris.unibe.ch/id/eprint/71679

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