Impact of cardiovascular risk factors on severity of peripheral artery disease

Wyss, Thomas Rudolf; Adam, Luise; Haynes, Alan G; Kucher, Nils; Silbernagel, Günther; Do, Dai-Do; Schmidli, Jürg; Baumgartner, Iris (2015). Impact of cardiovascular risk factors on severity of peripheral artery disease. Atherosclerosis, 242(1), pp. 97-101. Elsevier 10.1016/j.atherosclerosis.2015.07.002

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The development of peripheral artery disease is affected by the presence of cardiovascular risk factors. It is unclear, whether particular risk factors are leading to different clinical stages of peripheral artery disease. The aim of this retrospective cross-sectional study was to assess the association of cardiovascular risk factors with the presence of critical limb ischaemia.


The study cohort was derived from a consecutive registry of patients undergoing endovascular therapy in a tertiary referral centre between January 2000 and April 2014. Patients undergoing first-time endovascular intervention for chronic peripheral artery disease of the lower extremities were included. Univariate and multivariate logistic regression models were used to assess the association of age, sex, diabetes mellitus, hypertension, dyslipidaemia, smoking, and renal insufficiency with critical limb ischaemia vs. intermittent claudication.


A total of 3406 patients were included in the study (mean age 71.7 ± 11.8 years, 2075 [61%] male). There was a significant association of age (OR 1.67, 95%-CI 1.53-1.82, p < 0.001), male gender (OR 1.23, 95%-CI 1.04-1.47, p = 0.016), diabetes (OR 1.99, 95%-CI 1.68-2.36, p < 0.001) and renal insufficiency (OR 1.62, 95%-CI 1.35-1.96, p < 0.001) with the likelihood of critical limb ischaemia. Smoking was associated with intermittent claudication rather than critical limb ischaemia (OR 0.78, 95%-CI 0.65-0.94, p = 0.010), while hypertension and dyslipidaemia did not show an association with critical limb ischaemia.


In peripheral artery disease patients undergoing first-time endovascular treatment, age, male gender, diabetes, and renal insufficiency were the strongest predictors for the presence of critical limb ischaemia.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Wyss, Thomas Rudolf, Adam, Luise Leonore, Haynes, Alan, Kucher, Nils, Silbernagel, Günther, Do, Dai-Do, Schmidli, Jürg, Baumgartner, Iris


600 Technology > 610 Medicine & health








Catherine Gut

Date Deposited:

28 Sep 2015 11:45

Last Modified:

02 Mar 2023 23:26

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Peripheral artery disease; Diabetic vascular disease; Age; Diabetes mellitus; Renal insufficiency




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