Psychomotor retardation is linked to frontal alpha asymmetry in major depression

Cantisani, Andrea; König, Thomas; Horn, Helge Joachim; Müller, Thomas; Strik, Werner; Walther, Sebastian (2015). Psychomotor retardation is linked to frontal alpha asymmetry in major depression. Journal of Affective Disorders, 188, pp. 167-172. Elsevier 10.1016/j.jad.2015.08.018

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BACKGROUND Psychomotor disturbances are a main clinical feature of major depressive disorder (MDD) but little is known about their EEG signature. One of the most replicated EEG findings in MDD is resting frontal asymmetry in the alpha band (FAA), which is thought to be a correlate of withdrawal behavior and reduced approach motivation. The purpose of this study was to assess psychomotor alterations, alpha band power, FAA and investigate the association between them. METHODS 20 MDD patients and 19 healthy subjects were enrolled. Alpha power and FAA scores were calculated from a resting state EEG. Wrist actigraphy was recorded from the non-dominant arm for 24 h and activity level scores (AL) were extrapolated from the wakeful periods. RESULTS MDD patients had a left-lateralized frontal alpha activity and lower AL scores when compared to healthy subjects. A significant correlation was found between mean FAA and AL scores. A negative covariance between power in the lower alpha range and AL scores over the motor cortex bilaterally was detected. LIMITATIONS Relatively small sample size. Patients were pharmacologically treated with antidepressants. CONCLUSIONS This study replicates the finding of left-lateralized FAA and lower AL scores in MDD patients, and establishes the first evidence of significant correlations between alpha power, FAA scores and measures of motor activity, which may be interpreted as an expression of impaired motivational drive in MDD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

Cantisani, Andrea; König, Thomas; Horn, Helge Joachim; Müller, Thomas; Strik, Werner and Walther, Sebastian

Subjects:

500 Science
500 Science > 570 Life sciences; biology

ISSN:

0165-0327

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

30 Sep 2015 14:52

Last Modified:

30 Sep 2015 14:52

Publisher DOI:

10.1016/j.jad.2015.08.018

PubMed ID:

26363266

Uncontrolled Keywords:

Major depression; Psychomotor disturbances; Actigraphy; EEG; Frontal alpha asymmetry; Alpha oscillations

BORIS DOI:

10.7892/boris.72076

URI:

https://boris.unibe.ch/id/eprint/72076

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