Identification of a new genomic hot spot of evolutionary diversification of protein function.

Winkelmann, Aline; You, Xiantian; Grünewald, Nora; Häussler, Ute; Krestel, Heinz Eric; Haas, Carola A; Schwarz, Günter; Chen, Wei; Meier, Jochen C (2015). Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS ONE, 10(5), e0125413. Public Library of Science 10.1371/journal.pone.0125413

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Establishment of phylogenetic relationships remains a challenging task because it is based on computational analysis of genomic hot spots that display species-specific sequence variations. Here, we identify a species-specific thymine-to-guanine sequence variation in the Glrb gene which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. The resulting splice insert in the receptor for the inhibitory neurotransmitter glycine (GlyR) conveys synaptic receptor clustering and specific association with a particular synaptic plasticity-related splice variant of the postsynaptic scaffold protein gephyrin. This study identifies a new genomic hot spot which contributes to phylogenetic diversification of protein function and advances our understanding of phylogenetic relationships.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krestel, Heinz Eric

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

30 Sep 2015 13:36

Last Modified:

30 Sep 2015 13:36

Publisher DOI:

10.1371/journal.pone.0125413

PubMed ID:

25955356

BORIS DOI:

10.7892/boris.72091

URI:

https://boris.unibe.ch/id/eprint/72091

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