Myositides : What is the current situation?

Rösler, Kai Michael; Scheidegger, Olivier (2015). Myositides : What is the current situation? Zeitschrift für Rheumatologie, 74(6), pp. 496-506. Springer-Medizin-Verlag 10.1007/s00393-014-1547-0

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This article gives a review of the classification, diagnostic procedures and treatment of idiopathic inflammatory myopathies from a neurological point of view. The myositis syndromes can be subdivided into four groups, polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM) and necrotizing myopathy (NM), which substantially differ clinically and pathophysiologically. Myositis may also occur in association with cancer or autoimmune systemic diseases (overlap syndrome). Diagnosis of inflammatory myopathies is based on clinical symptoms, determination of creatine phosphokinase and acute phase parameters in blood (e.g. C-reactive protein and erythrocyte sedimentation rate), electromyography results and findings of magnetic resonance imaging (MRI) in muscle. A muscle biopsy is mandatory to confirm the diagnosis. High quality randomized controlled trials of treatment regimens for inflammatory myopathies are sparse; however, empirical experience indicates a clear effectiveness of immunosuppressive treatment of PM, DM and NM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Rösler, Kai Michael and Scheidegger, Olivier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-1855

Publisher:

Springer-Medizin-Verlag

Language:

German

Submitter:

Martin Zbinden

Date Deposited:

05 Oct 2015 09:53

Last Modified:

05 Oct 2015 09:53

Publisher DOI:

10.1007/s00393-014-1547-0

PubMed ID:

26184954

BORIS DOI:

10.7892/boris.72159

URI:

https://boris.unibe.ch/id/eprint/72159

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