The Social Life of African Trypanosomes

Imhof, Simon; Roditi, Isabel (2015). The Social Life of African Trypanosomes. Trends in parasitology, 31(10), pp. 490-498. Elsevier Current Trends 10.1016/j.pt.2015.06.012

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The unicellular parasite Trypanosoma brucei shuttles between its definitive host, the tsetse fly, and various mammals including humans. In the fly digestive tract, T. brucei must first migrate to the ectoperitrophic space, establish a persistent infection of the midgut and then migrate to the salivary glands before being transmitted to a new mammalian host. In 2010, it was shown that insect stages of the parasite (procyclic forms) exhibit social motility (SoMo) when cultured on a semi-solid surface, and it was postulated that this behaviour might reflect a migration step in the tsetse fly. Now, almost 5 years after the initial report, several new publications shed some light on the biological function of SoMo and provide insights into the underlying signalling pathways.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Imhof, Simon and Roditi, Isabel

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1471-4922

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Isabel Roditi

Date Deposited:

11 Mar 2016 09:39

Last Modified:

01 Nov 2016 02:30

Publisher DOI:

10.1016/j.pt.2015.06.012

PubMed ID:

26433252

BORIS DOI:

10.7892/boris.72267

URI:

https://boris.unibe.ch/id/eprint/72267

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