Rybaczek, Tina; Tangl, Stefan; Dobsak, Toni; Gruber, Reinhard; Kuchler, Ulrike (2015). The Effect of Parathyroid Hormone on Osseointegration in Insulin-Treated Diabetic Rats. Implant dentistry, 24(4), pp. 392-396. Lippincott Williams & Wilkins 10.1097/ID.0000000000000288
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OBJECTIVES
Uncontrolled diabetes mellitus is associated with impaired osseointegration. Diabetic individuals might benefit from bone anabolic therapies. Intermittent administration of 1-34 parathyroid hormone (PTH) stimulates bone formation in rodent models. However, this anabolic effect fails in diabetic rats. Whether the anabolic effect of PTH can be achieved in insulin-controlled diabetic rats has not been investigated yet.
MATERIALS AND METHODS
After diabetes induction with streptozotocin in 40 female Wistar rats, the animals were randomly divided into 4 groups: diabetes, diabetes plus PTH, insulin-treated diabetes, and insulin-treated diabetes plus PTH. After 1 week, miniscrews were inserted in the tibiae. Osmotic pumps with insulin or saline solution were implanted. Animals received 60 mg/kg PTH or saline solution. Histomorphometric analysis was performed.
RESULTS
In diabetic rats, no changes of medullary periimplant bone area or bone-to-implant contacts (BICs) were achieved with or without treatment with PTH. However, also animals treated with insulin failed to response significantly to PTH regarding bone area (7.4 ± 4.1% and 8.1 ± 4.1%) and BICs (33.7 ± 16.9% and 49.9 ± 11.9%).
CONCLUSION
These results demonstrate that the metabolic characteristics of the diabetic rats produced a condition unable to respond to PTH treatment, even when hyperglycemia was controlled with insulin.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology 04 Faculty of Medicine > School of Dental Medicine > Restorative Dentistry, Research |
UniBE Contributor: |
Gruber, Reinhard, Kuchler, Ulrike |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1056-6163 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
29 Oct 2015 13:23 |
Last Modified: |
05 Dec 2022 14:49 |
Publisher DOI: |
10.1097/ID.0000000000000288 |
PubMed ID: |
26126148 |
Uncontrolled Keywords: |
bone, teriparatide, rodent model, hyperglycemia |
BORIS DOI: |
10.7892/boris.72326 |
URI: |
https://boris.unibe.ch/id/eprint/72326 |
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