The Effect of Parathyroid Hormone on Osseointegration in Insulin-Treated Diabetic Rats.

Rybaczek, Tina; Tangl, Stefan; Dobsak, Toni; Gruber, Reinhard; Kuchler, Ulrike (2015). The Effect of Parathyroid Hormone on Osseointegration in Insulin-Treated Diabetic Rats. Implant dentistry, 24(4), pp. 392-396. Lippincott Williams & Wilkins 10.1097/ID.0000000000000288

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OBJECTIVES Uncontrolled diabetes mellitus is associated with impaired osseointegration. Diabetic individuals might benefit from bone anabolic therapies. Intermittent administration of 1-34 parathyroid hormone (PTH) stimulates bone formation in rodent models. However, this anabolic effect fails in diabetic rats. Whether the anabolic effect of PTH can be achieved in insulin-controlled diabetic rats has not been investigated yet. MATERIALS AND METHODS After diabetes induction with streptozotocin in 40 female Wistar rats, the animals were randomly divided into 4 groups: diabetes, diabetes plus PTH, insulin-treated diabetes, and insulin-treated diabetes plus PTH. After 1 week, miniscrews were inserted in the tibiae. Osmotic pumps with insulin or saline solution were implanted. Animals received 60 mg/kg PTH or saline solution. Histomorphometric analysis was performed. RESULTS In diabetic rats, no changes of medullary periimplant bone area or bone-to-implant contacts (BICs) were achieved with or without treatment with PTH. However, also animals treated with insulin failed to response significantly to PTH regarding bone area (7.4 ± 4.1% and 8.1 ± 4.1%) and BICs (33.7 ± 16.9% and 49.9 ± 11.9%). CONCLUSION These results demonstrate that the metabolic characteristics of the diabetic rats produced a condition unable to respond to PTH treatment, even when hyperglycemia was controlled with insulin.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Restorative Dentistry, Research

UniBE Contributor:

Gruber, Reinhard and Kuchler, Ulrike


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Eveline Carmen Schuler

Date Deposited:

29 Oct 2015 13:23

Last Modified:

25 Jan 2017 12:15

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

bone, teriparatide, rodent model, hyperglycemia




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