Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats

Fügl, Alexander; Gruber, Reinhard; Agis, Hermann; Lzicar, Hannah; Keibl, Claudia; Schwarze, Uwe Yacine; Dvorak, Gabriella (2015). Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats. Journal of clinical periodontology, 42(1), pp. 96-103. Wiley 10.1111/jcpe.12342

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AIM Vitamin D deficiency is considered to diminish bone regeneration. Yet, raising the serum levels takes months. A topic application of the active vitamin D metabolite, calcitriol, may be an effective approach. Thus, it becomes important to know the effect of vitamin D deficiency and local application on alveolar bone regeneration. MATERIAL AND METHODS Sixty rats were divided into three groups; two vitamin depletion groups and a control group. Identical single defects (2 mm diameter) were created in the maxilla and mandible treated with calcitriol soaked collagen in one deficiency group while in the other two groups not. Histomorphometric analysis and micro CTs were performed after 1 and 3 weeks. Serum levels of 25(OH)D3 and PTH were determined. RESULTS Bone formation rate significantly increased within the observation period in all groups. Bone regeneration was higher in the maxilla than in the mandible. However, bone regeneration was lower in the control group compared to vitamin depletion groups, with no significant effects by local administration of calcitriol (micro CT mandible p = 0.003, maxilla p < 0.001; histomorphometry maxilla p = 0.035, mandible p = 0.18). CONCLUSION Vitamin D deficiency not necessarily impairs bone regeneration in the rat jaw and a single local calcitriol application does not enhance healing.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Restorative Dentistry, Research

UniBE Contributor:

Gruber, Reinhard


600 Technology > 610 Medicine & health








Eveline Carmen Schuler

Date Deposited:

15 Feb 2016 10:54

Last Modified:

21 Sep 2017 11:23

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

1,25(OH)D3, bone healing calcitriol, supplementation, topic Administration, vitamin D deficiency




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