Molecular and cellular basis of bone resorption.

Gruber, Reinhard (2015). Molecular and cellular basis of bone resorption. Wiener medizinische Wochenschrift, 165(3-4), pp. 48-53. Springer 10.1007/s10354-014-0310-0

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Osteoclast research has an exciting history and a challenging future. More than 3 decades ago, it became evident that bone-resorbing osteoclasts are of hematopoietic origin and are ultimately linked to the "basic multicellular unit," where they team up with the other cell types, including bone-forming osteoblasts. Since 2 decades, we have learned about the signaling pathways controlling genes relevant for osteoclastogenesis and bone resorption. It took another decade until the hypothesized "osteoclast differentiation" factor was discovered and was translated into an approved pharmacologic strategy. Here, the focus is on another molecular target, cathepsin K, a cysteine protease being released by the osteoclast into the resorption compartment. Genetic deletion and pharmacological blocking of cathepsin K reduces bone resorption but with ongoing bone formation. This observation not only holds great promise to become a new pharmacologic strategy, but it also provides new insights into the coordinated work of cells in the "basic multicellular unit" and thus, bridges the history and future of osteoclast research. This article is a short primer on osteoclast biology for readers of the special issue on odanacatib, a cathepsin K inhibitor.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Gruber, Reinhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0043-5341

Publisher:

Springer

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

30 Oct 2015 14:39

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1007/s10354-014-0310-0

PubMed ID:

25223736

Uncontrolled Keywords:

Osteoclast, Bone remodeling - signaling, Resorption, Sealing zone, Ruffled boarder

BORIS DOI:

10.7892/boris.72334

URI:

https://boris.unibe.ch/id/eprint/72334

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