Role of hepatitis C virus genotype 3 in liver fibrosis progression - a systematic review and meta-analysis

Probst, A; Dang, T; Bochud, M; Egger, M; Negro, F; Bochud, P-Y (2011). Role of hepatitis C virus genotype 3 in liver fibrosis progression - a systematic review and meta-analysis. Journal of viral hepatitis, 18(11), pp. 745-759. Oxford: Blackwell Science 10.1111/j.1365-2893.2011.01481.x

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The progression of liver fibrosis in chronic hepatitis C has long been considered to be independent from viral genotypes. However, recent studies suggest an association between Hepatitis C virus (HCV) genotype 3 and accelerated liver disease progression. We completed a systematic review and meta-analysis of studies evaluating the association between HCV genotypes and fibrosis progression. PubMed, Embase and ISI Web of Knowledge databases were searched for cohort, cross-sectional and case-control studies on treatment-naïve HCV-infected adults in which liver fibrosis progression rate (FPR) was assessed by the ratio of fibrosis stage in one single biopsy to the duration of infection (single-biopsy studies) or from the change in fibrosis stage between two biopsies (paired biopsies studies). A random effect model was used to derive FPR among different HCV genotypes. Eight single-biopsy studies (3182 patients, mean/median duration of infection ranging from 9 to 21 years) and eight paired biopsies studies (mean interval between biopsies 2-12 years) met the selection criteria. The odds ratio for the association of genotype 3 with accelerated fibrosis progression was 1.52 (95% CI 1.12-2.07, P = 0.007) in single-biopsy studies and 1.37 (95% CI 0.87-2.17, P = 0.17) in paired biopsy studies. In conclusion, viral genotype 3 was associated with faster fibrosis progression in single-biopsy studies. This observation may have important consequences on the clinical management of genotype 3-infected patients. The association was not significant in paired biopsies studies, although the latter may be limited by important indication bias, short observation time and small sample size.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Egger, Matthias

ISSN:

1352-0504

Publisher:

Blackwell Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

10 Nov 2015 14:45

Publisher DOI:

10.1111/j.1365-2893.2011.01481.x

PubMed ID:

21992794

Web of Science ID:

000296464900001

BORIS DOI:

10.7892/boris.7303

URI:

https://boris.unibe.ch/id/eprint/7303 (FactScience: 212501)

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