An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.

Hauser, Christoph; Aebi, Suzanne; Mühlemann, Kathrin (2004). An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci. Antimicrobial agents and chemotherapy, 48(9), pp. 3563-3566. American Society for Microbiology 10.1128/AAC.48.9.3563-3566.2004

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Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x. Some isolates of this clone had evolved to higher resistance levels (penicillin MICs of 0.094 and 1 microg/ml), probably by acquisition of pbp2x fragments from local nonencapsulated pneumococci.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Hauser, Christoph and Mühlemann, Kathrin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Christoph Hauser

Date Deposited:

14 Jun 2018 09:14

Last Modified:

14 Jun 2018 09:14

Publisher DOI:

10.1128/AAC.48.9.3563-3566.2004

PubMed ID:

15328127

BORIS DOI:

10.7892/boris.73483

URI:

https://boris.unibe.ch/id/eprint/73483

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