Klenke, Frank Michael; Abdollahi, Amir; Bischof, Marc; Gebhard, Martha-Maria; Ewerbeck, Volker; Huber, Peter E; Sckell, Axel (2011). Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo. Strahlentherapie und Onkologie, 187(1), pp. 45-51. Heidelberg: Springer-Medizin-Verlag 10.1007/s00066-010-2116-3
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Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhance the response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases. Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective COX-2 inhibitor celecoxib in secondary bone tumors of a non-small cell lung carcinoma in vivo.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Klenke, Frank M. |
ISSN: |
0179-7158 |
Publisher: |
Springer-Medizin-Verlag |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:22 |
Last Modified: |
05 Dec 2022 14:06 |
Publisher DOI: |
10.1007/s00066-010-2116-3 |
PubMed ID: |
21234531 |
Web of Science ID: |
000286711600007 |
BORIS DOI: |
10.48350/7421 |
URI: |
https://boris.unibe.ch/id/eprint/7421 (FactScience: 212681) |
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