EEG marker of inhibitory brain activity correlates with resting-state cerebral blood flow in the reward system in major depression

Cantisani, Andrea; König, Thomas; Stegmayer, Katharina; Federspiel, Andrea; Horn, Helge Joachim; Müller, Thomas; Wiest, Roland; Strik, Werner; Walther, Sebastian (2016). EEG marker of inhibitory brain activity correlates with resting-state cerebral blood flow in the reward system in major depression. European archives of psychiatry and clinical neuroscience, 266(8), pp. 755-764. Springer 10.1007/s00406-015-0652-7

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Frontal alpha band asymmetry (FAA) is a marker of altered reward processing in major depressive disorder (MDD), associated with reduced approach behavior and withdrawal. However, its association with brain metabolism remains unclear. The aim of this study is to investigate FAA and its correlation with resting – state cerebral blood flow (rCBF). We hypothesized an association of FAA with regional rCBF in brain regions relevant for reward processing and motivated behavior, such as the striatum. We enrolled 20 patients and 19 healthy subjects. FAA scores and rCBF were quantified with the use of EEG and arterial spin labeling. Correlations of the two were evaluated, as well as the association with FAA and psychometric assessments of motivated behavior and anhedonia. Patients showed a left – lateralized pattern of frontal alpha activity and a correlation of FAA lateralization with subscores of Hamilton Depression Rating Scale linked to motivated behavior. An association of rCBF and FAA scores was found in clusters in the dorsolateral prefrontal cortex bilaterally (patients) and in the left medial frontal gyrus, in the right caudate head and in the right inferior parietal lobule (whole group). No correlations were found in healthy controls. Higher inhibitory right – lateralized alpha power was associated with lower rCBF values in prefrontal and striatal regions, predominantly in the right hemisphere, which are involved in the processing of motivated behavior and reward. Inhibitory brain activity in the reward system may contribute to some of the motivational problems observed in MDD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Cantisani, Andrea; König, Thomas; Stegmayer, Katharina; Federspiel, Andrea; Horn, Helge Joachim; Müller, Thomas; Wiest, Roland; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0940-1334

Publisher:

Springer

Language:

English

Submitter:

Thomas König

Date Deposited:

15 Dec 2015 10:43

Last Modified:

01 Jun 2017 15:35

Publisher DOI:

10.1007/s00406-015-0652-7

PubMed ID:

26590845

BORIS DOI:

10.7892/boris.74303

URI:

https://boris.unibe.ch/id/eprint/74303

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