Characterization of sialic acid index of plasma apolipoprotein J and phosphatidylethanol during alcohol detoxification--a pilot study

Wurst, Friedrich M; Thon, Natasha; Weinmann, Wolfgang; Tippetts, Scott; Marques, Paul; Hahn, Judith A; Alling, Christer; Aradottir, Steina; Hartmann, Susanne; Lakshman, Raj (2012). Characterization of sialic acid index of plasma apolipoprotein J and phosphatidylethanol during alcohol detoxification--a pilot study. Alcoholism: clinical and experimental research, 36(2), pp. 251-7. Oxford: Wiley-Blackwell 10.1111/j.1530-0277.2011.01618.x

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Apolipoprotein J (ApoJ) is a component of plasma high-density lipoproteins. Previous studies have shown progressive recovery of ApoJ sialic acid content with increased duration of alcohol abstinence. Therefore, the sialic acid index of plasma apolipoprotein J (SIJ) seems to be a promising alcohol biomarker. Phosphatidylethanol (PEth) is a direct ethanol metabolite and has recently attracted attention as a biomarker of prolonged intake of higher amounts of alcohol. The aim of the pilot study was to explore sensitivity, specificity, and normalization of SIJ and PEth in comparison with traditional and emerging biomarkers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Weinmann, Wolfgang

ISSN:

0145-6008

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

05 Dec 2022 14:06

Publisher DOI:

10.1111/j.1530-0277.2011.01618.x

PubMed ID:

21933198

Web of Science ID:

000299614700009

URI:

https://boris.unibe.ch/id/eprint/7442 (FactScience: 212704)

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