Acute kidney injury in three dogs after ingestion of a descaling agent containing maleic acid

Schweighauser, Ariane; Francey, Thierry; Gurtner, Corinne; Kupferschmidt, Hugo; Rauber-Lüthy, Christine (2015). Acute kidney injury in three dogs after ingestion of a descaling agent containing maleic acid. Veterinary Record Case Reports, 3(1), e000248. British Veterinary Association 10.1136/vetreccr-2015-000248

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Maleic acid (MA) is a common component of descaling products and is widely used in daily life. Accidental ingestion in relevant amounts does not play a major role in human beings; however, it seems to be highly toxic for dogs. It has been commonly used experimentally to induce Fanconi syndrome in dogs or small rodents. Two dogs were presented for acute kidney injury (AKI) after accidental ingestion of a descaling agent containing MA at an estimated amount of 70 mg/kg each. The third dog involved was euthanased by the referring veterinarian, and postmortem pathological analysis revealed severe acute tubular necrosis consistent with toxic nephropathy. The other dogs received symptomatic therapy for AKI including treatment with haemodialysis and showed complete normalisation of serum creatinine at a follow-up after five months. Renal damage can be very severe, but seems to be at least partially reversible and an attempt to treatment is warranted.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Schweighauser, Ariane; Francey, Thierry and Gurtner, Corinne

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

2052-6121

Publisher:

British Veterinary Association

Language:

English

Submitter:

Thierry Francey-Spicher

Date Deposited:

11 Jan 2016 12:30

Last Modified:

11 Jan 2016 12:30

Publisher DOI:

10.1136/vetreccr-2015-000248

BORIS DOI:

10.7892/boris.74495

URI:

https://boris.unibe.ch/id/eprint/74495

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