Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy

Equilino, Mirjam; Theodoloz, Vincent; Gorgas, Daniela; Doherr, Marcus G; Heilmann, Romy M; Suchodolski, Jan S; Steiner, Jörg M.; Burgener, Iwan A (2015). Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy. Journal of the American Veterinary Medical Association, 246(1), pp. 91-99. American Veterinary Medical Association 10.2460/javma.246.1.91

[img] Text
javma.246.1.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (306kB) | Request a copy

OBJECTIVE: To evaluate serum concentrations of biochemical markers and survival time in dogs with protein-losing enteropathy (PLE). DESIGN: Prospective study. ANIMALS: 29 dogs with PLE and 18 dogs with food-responsive diarrhea (FRD). PROCEDURES: Data regarding serum concentrations of various biochemical markers at the initial evaluation were available for 18 of the 29 dogs with PLE and compared with findings for dogs with FRD. Correlations between biochemical marker concentrations and survival time (interval between time of initial evaluation and death or euthanasia) for dogs with PLE were evaluated. RESULTS: Serum C-reactive protein concentration was high in 13 of 18 dogs with PLE and in 2 of 18 dogs with FRD. Serum concentration of canine pancreatic lipase immunoreactivity was high in 3 dogs with PLE but within the reference interval in all dogs with FRD. Serum α1-proteinase inhibitor concentration was less than the lower reference limit in 9 dogs with PLE and 1 dog with FRD. Compared with findings in dogs with FRD, values of those 3 variables in dogs with PLE were significantly different. Serum calprotectin (measured by radioimmunoassay and ELISA) and S100A12 concentrations were high but did not differ significantly between groups. Seventeen of the 29 dogs with PLE were euthanized owing to this disease; median survival time was 67 days (range, 2 to 2,551 days). CONCLUSIONS AND CLINICAL RELEVANCE: Serum C-reactive protein, canine pancreatic lipase immunoreactivity, and α1-proteinase inhibitor concentrations differed significantly between dogs with PLE and FRD. Most initial biomarker concentrations were not predictive of survival time in dogs with PLE.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Equilino, Mirjam; Theodoloz, Vincent and Schweizer, Daniela Esther

Subjects:

600 Technology > 630 Agriculture

ISSN:

0003-1488

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Daniela Esther Schweizer

Date Deposited:

11 Jan 2016 12:47

Last Modified:

01 Nov 2017 10:41

Publisher DOI:

10.2460/javma.246.1.91

PubMed ID:

25517330

BORIS DOI:

10.7892/boris.74511

URI:

https://boris.unibe.ch/id/eprint/74511

Actions (login required)

Edit item Edit item
Provide Feedback