Developments in mechanical thrombectomy devices for the treatment of acute ischemic stroke

Mordasini, Pasquale; Gralla, Jan (2016). Developments in mechanical thrombectomy devices for the treatment of acute ischemic stroke. Expert review of medical devices, 13(1), pp. 71-81. Taylor & Francis 10.1586/17434440.2015.1124019

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Several recent prospective randomized controlled trials of endovascular stroke therapy using latest generation thrombectomy devices, so called stent-retrievers, have shown significantly improved clinical outcome compared to the standard treatment with intra-venous thrombolysis using r-tPA alone. Despite some differences in inclusion criteria between these studies, all required non-invasive vessel imaging to proof occlusion of a major brain supplying vessel. Furthermore, in most studies additional imaging techniques were used to exclude patients with already established large cerebral infarction or unfavorable collateral or penumbral status. Patients with small infarct volume, severe neurological deficits and in whom thrombectomy can be initiated within the first 6 hours after symptom onset seem to benefit the most. Therefore, mechanical thrombectomy using stent-retrievers in addition to intra-venous thrombolysis is recommended for the treatment of acute ischemic stroke with proven major vessel occlusion in the anterior circulation.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Mordasini, Pasquale and Gralla, Jan


600 Technology > 610 Medicine & health




Taylor & Francis




Martin Zbinden

Date Deposited:

14 Jan 2016 09:26

Last Modified:

26 Feb 2018 15:44

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Acute ischemic stroke, endovascular stroke treatment, mechanical thrombectomy, stent-retriever, proximal thrombectomy, distal thrombectomy, clinical trials, clinical outcome


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