Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study.

Bauer, Lukas; Takacs, Agnes; Slotta-Huspenina, Julia; Langer, Rupert; Becker, Karen; Novotny, Alexander; Ott, Katja; Walch, Axel; Hapfelmeier, Alexander; Keller, Gisela (2015). Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study. Frontiers in oncology, 5(94), p. 94. Frontiers Research Foundation 10.3389/fonc.2015.00094

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BACKGROUND NOTCH signaling can exert oncogenic or tumor suppressive functions and can contribute to chemotherapy resistance in cancer. In this study, we aimed to clarify the clinicopathological significance and the prognostic and predictive value of NOTCH1 and NOTCH2 expression in gastric cancer (GC). METHODS NOTCH1 and NOTCH2 expression was determined immunohistochemically in 142 primarily resected GCs using tissue microarrays and in 84 pretherapeutic biopsies from patients treated by neoadjuvant chemotherapy. The results were correlated with survival, response to therapy, and clinico-pathological features. RESULTS Primarily resected patients with NOTCH1-negative tumors demonstrated worse survival. High NOTCH1 expression was associated with early-stage tumors and with significantly increased survival in this subgroup. Higher NOTCH2 expression was associated with early-stage and intestinal-type tumors and with better survival in the subgroup of intestinal-type tumors. In pretherapeutic biopsies, higher NOTCH1 and NOTCH2 expression was more frequent in non-responding patients, but these differences were statistically not significant. CONCLUSION Our findings suggested that, in particular, NOTCH1 expression indicated good prognosis in GC. The close relationship of high NOTCH1 and NOTCH2 expression with early tumor stages may indicate a tumor-suppressive role of NOTCH signaling in GC. The role of NOTCH1 and NOTCH2 in neoadjuvantly treated GC is limited.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Langer, Rupert


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




Frontiers Research Foundation




Doris Haefelin

Date Deposited:

07 Jan 2016 16:18

Last Modified:

26 Jun 2016 02:09

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

chemotherapy; immunohistochemistry; prognosis; receptor NOTCH1; receptor NOTCH2; stomach neoplasms




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