Serum Testosterone Levels and Symptom-Based Depression Subtypes in Men

Rodgers, Stephanie; Grosse Holtforth, Martin; Hengartner, Michael P.; Müller, Mario; Aleksandrowicz, Aleksandra A.; Rössler, Wulf; Ajdacic-Gross, Vladeta (2015). Serum Testosterone Levels and Symptom-Based Depression Subtypes in Men. Frontiers in psychiatry, 6(61), pp. 1-9. Frontiers 10.3389/fpsyt.2015.00061

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The main objective of this preliminary study was to further clarify the association between testosterone (T) levels and depression by investigating symptom-based depression subtypes in a sample of 64 men. The data were taken from the ZInEP epidemiology survey. Gonadal hormones of a melancholic (n  = 25) and an atypical (n = 14) depression subtype, derived from latent class analysis, were compared with those of healthy controls (n  = 18). Serum T was assayed using an enzyme-linked immunosorbent assay procedure. Analysis of variance, analysis of covariance, non-parametrical tests, and generalized linear regression models were performed to examine group differences. The atypical depressive subtype showed significantly lower T levels compared with the melancholic depressives. While accumulative evidence indicates that, beyond psychosocial characteristics, the melancholic and atypical depressive subtypes are also distinguishable by biological correlates, the current study expanded this knowledge to include gonadal hormones. Further longitudinal research is warranted to disclose causality by linking the multiple processes in pathogenesis of depression.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

Grosse Holtforth, Martin

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1664-0640

Publisher:

Frontiers

Language:

English

Submitter:

Adriana Biaggi

Date Deposited:

22 Jan 2016 16:14

Last Modified:

22 Jan 2016 16:14

Publisher DOI:

10.3389/fpsyt.2015.00061

PubMed ID:

25999864

Uncontrolled Keywords:

testosterone, depression, subtypes, epidemiology, cross-sectional study

BORIS DOI:

10.7892/boris.74720

URI:

https://boris.unibe.ch/id/eprint/74720

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