Primary structure and evolutionary relationship between the adult alpha-globin genes and their 5'-flanking regions of Xenopus laevis and Xenopus tropicalis

Stalder, J; Wirthmüller, U; Beck, J; Gruber, Andreas; Meyerhof, W; Knöchel, W; Weber, R (1988). Primary structure and evolutionary relationship between the adult alpha-globin genes and their 5'-flanking regions of Xenopus laevis and Xenopus tropicalis. Journal of molecular evolution, 28(1-2), pp. 64-71. Springer

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To investigate the evolution of globin genes in the genus Xenopus, we have determined the primary structure of the related adult alpha I- and alpha II-globin genes of X. laevis and of the adult alpha-globin gene of X. tropicalis, including their 5'-flanking regions. All three genes are comprised of three exons and two introns at homologous positions. The exons are highly conserved and code for 141 amino acids. By contrast, the corresponding introns vary in length and show considerable divergence. Comparison of 900 bp of the 5'-flanking region revealed that the X. tropicalis gene contains a conserved proximal 310-bp promoter sequence, comprised of the canonical TATA and CCAAT motifs at homologous positions, and five conserved elements in the same order and at similar positions as previously shown for the corresponding genes of X. laevis. We therefore conclude that these conserved upstream elements may represent regulatory sequences for cell-specific regulation of the adult Xenopus globin genes.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Gruber, Andreas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0022-2844

Publisher:

Springer

Language:

English

Submitter:

Andreas Gruber

Date Deposited:

28 Jan 2016 15:35

Last Modified:

28 Jan 2016 15:35

PubMed ID:

3148743

URI:

https://boris.unibe.ch/id/eprint/74829

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