Ma, Liang; Yu, Zipu; Huber, Christoph; Li, Chengchen; Qian, Linfeng; Jiang, Jianjie; Zou, Yu (2015). New Self-Expanding Transcatheter Valve for Off-Pump Transatrial Mitral Valve-In-Ring Implantation. Cardiology, 132(4), pp. 221-227. Karger 10.1159/000433595
|
Text
433595.pdf - Published Version Available under License Publisher holds Copyright. Download (593kB) | Preview |
OBJECTIVES
To validate a self-expanding transcatheter valve for off-pump transatrial mitral valve-in-ring (VIR) implantation via a left thoracotomy.
METHODS
Mitral valve annuloplasty was performed via sternotomy during cardiopulmonary bypass on 9 pigs. After successful weaning from extracorporal circulation, the custom-made, self-expanding transcatheter VIR device was deployed under fluoroscopic guidance within the annuloplasty ring via a left thoracotomy. Hemodynamic data before and after the implantation were recorded. Mitral annulus diameter and valve area were measured by echocardiography. Transvalvular and left-ventricular outflow-tract pressure gradient were measured invasively.
RESULTS
Eight successful implantations were performed. Implantation failed in 1 pig because of difficulty with technical delivery of the sheath. Mean transatrial procedure time was 12.6 ± 1.7 min. Hemodynamic status during transatrial implantation was stable, and differences were not statistically significant. Mean mitral annulus diameter and mean mitral orifice area were 2.32 ± 0.2 and 3.84 ± 0.55 cm2, respectively. Mild regurgitation was detected in 7 animals and moderate regurgitation in 1. Mean gradients were 6.1 ± 5.0 mm Hg across the device. Postmortem examination confirmed adequate positioning of devices within the annuloplasty ring.
CONCLUSIONS
This custom-made transcatheter device allows for safe and reproducible off-pump transatrial mitral VIR implantations. Transatrial access is a promising route to facilitate VIR implantations. Our custom-made stent-valve may be suitable for VIR procedures.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery |
UniBE Contributor: |
Huber, Christoph |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0008-6312 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Daniela Huber |
Date Deposited: |
02 Feb 2016 16:04 |
Last Modified: |
27 Feb 2024 14:29 |
Publisher DOI: |
10.1159/000433595 |
PubMed ID: |
26304619 |
BORIS DOI: |
10.7892/boris.74951 |
URI: |
https://boris.unibe.ch/id/eprint/74951 |
Actions (login required)
 |
Edit item |