Computed Ultrasound Tomography in Echo Mode for Imaging Speed of Sound Using Pulse-Echo Sonography: Proof of Principle

Jaeger, Michael; Held, Kai Gerrit; Peeters, Sara Elisa; Preisser, Stefan; Grünig, Michael; Frenz, Martin (2015). Computed Ultrasound Tomography in Echo Mode for Imaging Speed of Sound Using Pulse-Echo Sonography: Proof of Principle. Ultrasound in medicine & biology, 41(1), pp. 235-250. Elsevier 10.1016/j.ultrasmedbio.2014.05.019

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The limitations of diagnostic echo ultrasound have motivated research into novel modalities that complement ultrasound in a multimodal device. One promising candidate is speed of sound imaging, which has been found to reveal structural changes in diseased tissue. Transmission ultrasound tomography shows speed of sound spatially resolved, but is limited to the acoustically transparent breast. We present a novel method by which speed-of-sound imaging is possible using classic pulse-echo equipment, facilitating new clinical applications and the combination with state-of-the art diagnostic ultrasound. Pulse-echo images are reconstructed while scanning the tissue under various angles using transmit beam steering. Differences in average sound speed along different transmit directions are reflected in the local echo phase, which allows a 2-D reconstruction of the sound speed. In the present proof-of-principle study, we describe a contrast resolution of 0.6% of average sound speed and a spatial resolution of 1 mm (laterally) × 3 mm (axially), suitable for diagnostic applications.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics

UniBE Contributor:

Jaeger, Michael; Held, Kai Gerrit; Peeters, Sara Elisa; Preisser, Stefan; Grünig, Michael and Frenz, Martin

Subjects:

600 Technology > 620 Engineering
500 Science
500 Science > 530 Physics

ISSN:

0301-5629

Publisher:

Elsevier

Language:

English

Submitter:

Martin Frenz-Lips

Date Deposited:

04 Feb 2016 10:54

Last Modified:

04 Feb 2016 10:54

Publisher DOI:

10.1016/j.ultrasmedbio.2014.05.019

URI:

https://boris.unibe.ch/id/eprint/74982

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