Outcome in neonates with necrotizing enterocolitis and patent ductus arteriosus.

Kessler, Ulf; Schulte, Franzisca; Cholewa, Dietmar; Nelle, Mathias; Schaefer, Stephan C; Klimek, Peter Michael; Berger, Steffen Michael (2016). Outcome in neonates with necrotizing enterocolitis and patent ductus arteriosus. World journal of pediatrics WJP, 12(1), pp. 55-59. Institute of Pediatrics 10.1007/s12519-015-0059-6

[img]
Preview
Text
Outcome in neonates with necrotizing enterocolitis.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (4MB) | Preview

BACKGROUND There is no agreement of the influence of patent ductus arteriosus (PDA) on outcomes in patients with necrotizing enterocolitis (NEC). In this study, we assessed the influence of PDA on NEC outcomes. METHODS A retrospective study of 131 infants with established NEC was performed. Outcomes (death, disease severity, need for surgery, hospitalization duration), as well as multiple clinical parameters were compared between NEC patients with no congenital heart disease (n=102) and those with isolated PDA (n=29). Univariate, multivariate and stepwise logistic regression analyses were performed. RESULTS Birth weight and gestational age were significantly lower in patients with PDA [median (95% CI): 1120 g (1009-1562 g), 28.4 wk (27.8-30.5 wk)] than in those without PDA [median (95% CI): 1580 g (1593-1905 g), 32.4 wk (31.8-33.5 wk); P<0.05]. The risk of NEC-attributable fatality was higher in NEC patients with PDA (35%) than in NEC patients without PDA (14%)[univariate odds ratio (OR)=3.3, 95% CI: 1.8-8.6, P<0.05; multivariate OR=2.4, 95% CI: 0.82-2.39, P=0.111]. Significant independent predictors for nonsurvival within the entire cohort were advanced disease severity stage III (OR=27.9, 95% CI: 7.4-105, P<0.001) and birth weight below 1100 g (OR=5.7, 95% CI: 1.7-19.4, P<0.01). CONCLUSIONS In patients with NEC, the presence of PDA is associated with an increased risk of death. However, when important differences between the two study groups are controlled, only birth weight and disease severity may independently predict mortality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Research Group Pediatric Surgery
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Kessler, Ulf; Schulte, Franzisca; Cholewa, Dietmar; Nelle, Mathias; Klimek, Peter Michael and Berger, Steffen Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1708-8569

Publisher:

Institute of Pediatrics

Language:

English

Submitter:

Christoph Steffen

Date Deposited:

15 Feb 2016 09:27

Last Modified:

19 Dec 2016 02:30

Publisher DOI:

10.1007/s12519-015-0059-6

PubMed ID:

26684305

Uncontrolled Keywords:

congenital heart disease; necrotizing enterocolitis; neonatal mortality; patent ductus arteriosus

BORIS DOI:

10.7892/boris.75066

URI:

https://boris.unibe.ch/id/eprint/75066

Actions (login required)

Edit item Edit item
Provide Feedback