Activation of common signaling pathways during remodeling of the heart and the bladder

Köck, Ivonne; Burkhard, Fiona C.; Monastyrskaya-Stäuber, Katia (2016). Activation of common signaling pathways during remodeling of the heart and the bladder. Biochemical pharmacology, 102, pp. 7-19. Elsevier 10.1016/j.bcp.2015.09.012

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The heart and the urinary bladder are hollow muscular organs, which can be afflicted by pressure overload injury due to pathological conditions such as hypertension and bladder outlet obstruction. This increased outflow resistance induces hypertrophy, marked by dramatic changes in the organs' phenotype and function. The end result in both the heart and the bladder can be acute organ failure due to advanced fibrosis and the subsequent loss of contractility. There is emerging evidence that microRNAs (miRNAs) play an important role in the pathogenesis of heart failure and bladder dysfunction. MiRNAs are endogenous non-coding single-stranded RNAs, which regulate gene expression and control adaptive and maladaptive organ remodeling processes. This Review summarizes the current knowledge of molecular alterations in the heart and the bladder and highlights common signaling pathways and regulatory events. The miRNA expression analysis and experimental target validation done in the heart provide a valuable source of information for investigators working on the bladder and other organs undergoing the process of fibrotic remodeling. Aberrantly expressed miRNA are amendable to pharmacological manipulation, offering an opportunity for development of new therapies for cardiac and bladder hypertrophy and failure.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Köck, Ivonne; Burkhard, Fiona C. and Monastyrskaya-Stäuber, Katia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-2952

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

08 Feb 2016 14:12

Last Modified:

30 Sep 2017 09:00

Publisher DOI:

10.1016/j.bcp.2015.09.012

PubMed ID:

26390804

Uncontrolled Keywords:

Bladder, Fibrosis, Gene expression, Heart, Obstruction, Pressure overload, Signaling, miRNA

BORIS DOI:

10.7892/boris.75187

URI:

https://boris.unibe.ch/id/eprint/75187

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