Interplay between receptor tyrosine kinases and hypoxia signaling in cancer.

Glück, Astrid Andreina; Aebersold, Daniel; Zimmer, Yitzhak; Medova, Michaela (2015). Interplay between receptor tyrosine kinases and hypoxia signaling in cancer. The international journal of biochemistry & cell biology, 62, pp. 101-114. 10.1016/j.biocel.2015.02.018

[img] Text
1-s2.0-S1357272515000618-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy
GlÃck_et_al_2015.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (773kB) | Preview

Deregulated signaling via receptor tyrosine kinase (RTK) pathways is prevalent in numerous types of human cancers and is commonly correlated with worst prognosis, resistance to various treatment modalities and increased mortality. Likewise, hypoxic tumors are often manifested by aggressive mode of growth and progression following an adaptive genetic reprogramming with consequent transcriptional activation of genes encoding proteins, which support tumor survival under low oxygen-related conditions. Consequently, both the hypoxia-inducible factor (HIF) system, which is the major mediator of hypoxia-related signaling, and numerous RTK systems are considered critical molecular targets in current cancer therapy. It is now evident that there is an intricate molecular crosstalk between RTKs and hypoxia-related signaling in the sense that hypoxia can activate expression of particular RTKs and/or their corresponding ligands, while some RTK systems have been shown to trigger activation of the HIF machinery. Moreover, signaling regulation of some RTK systems under hypoxic conditions has also been documented to take place in a HIF-independent manner. With this review we aim at overviewing the most current observations on that topic and highlight the importance of the potential co-drugging the HIF system along with particular relevant RTKs for better tumor growth control.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Glück, Astrid Andreina; Aebersold, Daniel; Zimmer, Yitzhak and Medova, Michaela


600 Technology > 610 Medicine & health






Beatrice Scheidegger

Date Deposited:

06 Apr 2016 11:49

Last Modified:

01 Jun 2016 02:30

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cancer, HIF system, Hypoxia, RTKs, VEGF




Actions (login required)

Edit item Edit item
Provide Feedback