Advances and challenges in skeletal muscle angiogenesis.

Olfert, I Mark; Baum, Oliver; Hellsten, Ylva; Egginton, Stuart (2015). Advances and challenges in skeletal muscle angiogenesis. American journal of physiology - heart and circulatory physiology, 310(3), H326-H336. American Physiological Society 10.1152/ajpheart.00635.2015

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The role of capillaries is to serve as the interface for delivery of oxygen and removal of metabolites to/from tissues. During the past decade there has been a proliferation of studies that have advanced our understanding of angiogenesis demonstrating tissue capillary supply is under strict control during health, but poorly controlled in disease - resulting in either excessive capillary growth (pathological angiogenesis) or losses in capillarity (rarefaction). Given that skeletal muscle comprises nearly 40% of body mass in humans, skeletal muscle capillary density has a significant impact on metabolism, endocrine function, and locomotion, and is tightly regulated at many different levels. Skeletal muscle is also high adaptable, and thus one of the few organ systems which can be experimentally manipulated (e.g. by exercise) to study physiologic regulation of angiogenesis. This review will focus on 1) the methodological concerns that have arisen in determining skeletal muscle capillarity, and 2) highlight the concepts that are reshaping our understanding of the angio-adaptation process. We also summarize selected new findings (physical influences, molecular changes and ultrastructural rearrangement of capillaries) that identify areas of future research with the greatest potential to expand our understanding of how angiogenesis is normally regulated, and that may also help to better understand conditions of uncontrolled (pathologic) angiogenesis.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Baum, Oliver


600 Technology > 610 Medicine & health




American Physiological Society




Benoît Zuber

Date Deposited:

09 Feb 2016 11:22

Last Modified:

11 May 2016 16:58

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

exercise; human; rodent; training




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